Pramipexole for Treatment Resistant Depression

How to use Pramipexole

  • Selective D3 agonist thought to be related to hedonic drive. 
  • FDA approved for Parkinson’s disease and restless leg syndrome 
  • 5 randomized controlled trials indicating effectiveness in depression as monotherapy or adjunctive therapy and in bipolar disorder as adjunctive therapy with a mood stabilizer 
  • Side effects; nausea, hypotension, and fatigue, titrate slowly and give the dose at night 
  • Start with 0.125-0.25 mg QHS and rise by 0.25 mg every 5-7 days towards a target dose of 0.75-2 mg QHS 
  • Watch for hedonistic homeostatic dysregulation (HDD) including pathological gambling and shopping

5 Stage Method for Treatment Resistant Depression (TRD)

I get a lot of questions that go something like this, I’ve been on X, Y, Z medications and nothing seems to help. It seems that what most are asking about is what is the algorithm for treating depression and when does it become treatment resistant. This video will provide a look at what treatment resistant depression is and provides a 5-stage strategy to medication selection.  

Powered by WordPress.com.

Up ↑

%d bloggers like this: