🔹 Up to 50% of patients attempt suicide
🔹 Around 10% die by suicide
The InterSePT trial directly addressed this crisis by comparing clozapine vs olanzapine in high-risk patients—all with recent suicidal ideation or attempts. Notably, only 27% were treatment-resistant.
✅ Clozapine led to a 25% reduction in suicidal behaviors—a game-changer.
📌 This led to FDA approval for clozapine in reducing suicidality in schizophrenia.
Let’s stop thinking of clozapine only as a last resort. Sometimes, it’s exactly what’s needed—not later, but now.