Suicidal Signals with Semaglutide? Experts Say, Don’t Panic Yet!

I recently had a case involving a person with no prior history of mental illness who suddenly developed acute suicidal thoughts. The only recent change in their life was starting a glucagon-like peptide-1 (GLP-1) agonist for diabetes. They reported noticeable mood changes and even suspected the medication was the cause based on their own experience. While we can’t draw any definitive conclusions about causation at this point, it’s reasonable to advise people, especially those with a psychiatric history, to carefully monitor for mood changes and suicidal thoughts when starting this type of medication.

https://www.medscape.com/viewarticle/signal-suicidality-glp-1-ra-semaglutide-experts-urge-caution-2024a1000fa7?ecd=wnl_peerpulse_pos1_240823_etid6769391&uac=267049CZ&impID=6769391