Be Cautious with Gabapentin in Patients on MAT for Opioid Use Disorder 

In my practice, I frequently see patients on Medication-Assisted Treatment (MAT) for opioid use disorder, whether it’s Suboxone or methadone, also being prescribed high-dose gabapentin—often without a clear indication for its use. This raises some serious red flags. ⚠️

While gabapentin can be useful in certain situations, we know there’s an increased risk of overdose when it’s combined with opioids, especially in those with a history of opioid use disorder. Gabapentin can suppress the central nervous system, making it more dangerous in combination with other sedating medications.

If there’s no solid reason for the prescription, it’s best to steer clear. Always prioritize safety and question if gabapentin is truly necessary in these cases. Let’s keep patient care and harm reduction at the forefront.

💡 Key takeaway: If there’s no clear indication, think twice before prescribing gabapentin to someone on MAT. Their safety depends on it.